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The homeopathy debate…

What is it about homeopathy that has enabled it to survive over 200 years of usage in spite of having what some current studies insist is no greater effect than placebo? Is it simply that the placebo, or essentially our own immune system, is that effective when given a little encouragement?

My overall experience in using these medications with clients has been surprisingly positive. I was first introduced to the medication system in the mid-nineties when we had just opened a new pharmacy. My husband, who is also my business partner (and a non-pharmacist), had noticed the rising interest in natural remedies and, in spite of my hesitation, insisted that we should stock homeopathy as well as herbal medicines.

As a pharmacist, I had a hard time getting my head around the way homeopathy was prepared, and the Latin names and different preparations were confusing to me, but I agreed to give it a try. Of course, we didn’t have the “meta-analysis” studies that we have today, which would likely have convinced me to do otherwise.

Initially, my role was simply to provide specific medications that clients came in looking for, or I would consult homeopathy texts to help clients determine which medication would specifically be recommended for them when someone asked. Although I didn’t have an overwhelmingly large number of clients and didn’t specifically track their responses, it seemed that I received far more positive feedback than negative.

Very early on, I had a chat about homeopathy with a pharmacy student who was with me for the summer. “I think it’s a crock,” she said. Then a client came in, looking for more Rhus Toxicodedron to take along with his standard rheumatoid arthritis medications. He felt that he was sleeping better with the homeopathy added.

My pharmacy student decided to take some home for her mom to try for her arthritis. Within a week or two, she marvelled that several spots of eczema that she had had for several years had disappeared! We consulted a text and discovered that Rhus Toxicodendron was also useful for the crusted-over stage of eczema! Our little “N=1” study had produced results, although not what we expected. We certainly couldn’t credit the placebo response in this case, since none of us knew this agent was recommended for eczema. I suppose one could say it was just chance, and it was going to disappear anyway on its own, but it seemed more than that.

One type of situation where I found homeopathy particularly useful was in cases where it was not safe to recommend standard medication. An example of this would be a client with high blood pressure or diabetes who was looking for something for a low-level sinus problem (where my questioning had determined that it was unlikely they had a sinus infection). I would cautiously suggest a combination sinus product with several homeopathic ingredients, since I did not have the time or expertise to do a full homeopathic assessment to determine the single most recommended ingredient. After a few such recommendations, this product quickly became one of my best-selling sinus medications. It was obvious that people were being referred by others who had tried it. “My friend/neighbour/relative told me I should get some of the sinus medication they bought here, called ‘Sinus-something’ (Sinusalia),” they would often say.

Comparing to other accepted products…
To be fair to homeopathy, I should mention that there are a large number of other questionable medications being carried in pharmacies. Pharmacists happily recommended children’s DM and decongestant products for years, only to find out that they were ineffective and did more harm than good. I even gave them to my own children, believing that they would help. And perhaps they did, given that the care and attention that I administered them with probably helped to stimulate a good placebo response.

And what about all the vitamins that are stocked in pharmacies? There has been plenty of educated commentary advising that we should be able to get all the nutrients we need from our food, making multivitamins unnecessary for most people.

To be in compliance with Natural and Nonprescription Health Directorate guidelines for obtaining a Natural Product Number (NPN), most herbal products no longer make any claims at all on their labels, presumably leaving other sources (such as websites, and advertising) to promote claims that are not acceptable to Health Canada. This leaves the consumer to search out whatever information they might find, often on the Internet or through word of mouth. That’s not always an ideal situation, depending on the source!

As a pharmacist, I subscribed to reputable sites and bought approved texts on herbal medicines so I could give evidence-based replies to questions about herbal medicines. I tried to do the same with homeopathic medicines, and purchased several standard and newly printed texts on homeopathy.

Knowing how highly diluted homeopathic medications are prepared, I had difficulty understanding how they possibly could work. There is a parallel with vaccines, where the agent that causes the problem is basically destroyed and then made into a solution that then stimulates the immune system to do the action we desire. This seemed to be a plausible explanation for how homeopathy could work, but why would a more dilute solution give a stronger effect rather than a weaker one?

Confounding my understanding was the existence (although rare) of the “exacerbation reaction,” which is reported in the literature and was experienced by one of my clients who tried an allergy product. How could a substance that is diluted beyond Avogadro’s number (leaving it unlikely to contain even a single molecule of the original substance) cause her allergic symptoms to strongly intensify only minutes after taking a homeopathic medicine?

Could it be that standard testing methods cannot be used for homeopathy due to its individualization?

Homeopathic medications are used around the world far more commonly than they are in North America. England even has homeopathic hospitals, described to me by a pharmacy student who had done a rotation in such a hospital. Another student from India told me that homeopathic medicines were routinely used at home.

One of my best clients was a veterinarian who regularly used homeopathic medications with his animal patients—if the action of homeopathy relies only the placebo response, how could they work in an animal?

Are we missing something? Could it be that standard testing methods cannot be used for homeopathy due to its individualization? Do we need to, perhaps, include the ability of the immune system to respond in our attempts to prove or disprove this system? More questions than answers…

The bottom line…

So, while other pharmacists may make a different decision, I found a way to use these medications safely and productively in my pharmacy practice. When someone asks for advice on a homeopathic product, I make sure they are using it for a self-limiting condition or at least as an adjunct to a standard treatment.

And I find homeopathic remedies are useful to have available when a client is determined that they want to take a medication, but it is unsafe for them to take the standard non-prescription medication because of an existing condition or another medication they are taking.

I also make sure that they know what non-drug measures are helpful for their condition. In this way, I can try to ensure that they benefit from having visited the pharmacy and that their treatment doesn’t do more harm than good.

An important part of the decision to use homeopathy, is making sure that the condition is self-limiting. In other words, only use homeopathy for conditions that the immune system can overcome. At the very least, given the power of the placebo, the fact that they are taking something may well mean that they will get better sooner!

Previously published in Pharmacy Practice Plus journal for pharmacists

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COLD SORES

Cold sores may occur anywhere on the body, but they most often appear on the gums, lips, around the mouth, nose, cheeks or fingers. Infection begins with a prodrome (tingling, burning or stinging sensation) which may last two hours to two days, followed by redness, swelling and blisters that break and ooze, forming a crust that eventually sloughs off. The entire cycle usually lasts seven to 10 days.

Ninety percent of people get at least one cold sore in their lives. The initial infection, which most often occurs between six months and three years of age, is generally worse than reoccurrences. The first episode usually occurs inside the mouth and can involve pain, fever, and swollen lymph nodes. It may be severe enough to cause difficulty swallowing. With both initial infections and cold sore reoccurrences, symptoms last about a week and resolve spontaneously.

Outbreaks can be triggered by trauma to the skin, menstruation, sun exposure, stress, illness, fever and other causes that contribute to reduced immune system activity. Most people have about two reoccurrences per year, but 5-10% of sufferers have more than six episodes yearly.

“Once a person has been exposed to the herpes simplex virus, it remains in the body and can be reactivated at any time.”

Cold sores are contagious and can be spread by direct contact with infected saliva or skin, or by contact with an item (such as a towel) that has been contaminated with the infection. There are two variations of the Herpes Simplex virus, called Type I (HSV-1) and Type II (HSV-2). Initially, HSV-1 was found on the face, while HSV-2 was found only in the genital area of patients. Now, however, both variants can be found in either location, but HSV-1 is most common. This article will discuss only oral infections.

Treating cold sores
Treatment approaches include reducing reoccurrences, decreasing pain, preventing secondary infection and reducing duration of the infection.

One approach to reducing the frequency of these embarrassing, unsightly infections is to identify and avoid triggers. General measures to maintain a healthy immune system, such as getting plenty of rest and paying attention to good nutrition, particularly during periods of increased stress, can be suggested. Sun exposure is a common trigger, so reducing UV light exposure by applying a sun block to the affected area year-round can help prevent outbreaks. In patients with a reduced immune response, prescription antiviral medications may be required.

A novel approach to preventing cold sores is the use of “thermal defence technology.” The Intercept-CS device uses the “heat shock” response to thermal stimulation (given in three 30-second treatments at five-minute intervals) to promote the production of heat shock proteins. These react with the immune system to help recognize and kill virus-infected cells without damaging healthy cells. It’s recommended that the treatment be performed within the first three hours of the prodrome phase of cold sore development. A clinical study cited on the product website demonstrated that this treatment could prevent 46% of cold sores from developing further. The downside is the cost: $99.00 per unit plus two treatment activators, and $45.00 for two replacement treatment activators. It is also only available through selected retail outlets.

Many OTC cold sore preparations are aimed mainly at reducing discomfort. These products contain a local anesthetic (such as benzocaine, lidocaine, benzyl alcohol, camphor, menthol or phenol) to decrease pain and itching, or are designed to form a protective film over the sore to reduce contact with irritating substance. Products of this type include Zilactin, Anbesol, Orajel, Tanac and Fletcher’s Sore Mouth Medicine.

Two products, Abreva and Lipactin, have been shown in clinical studies to shorten the duration of cold sores. Abreva contains docosanol 10%, an active ingredient that blocks viruses from penetrating into cells, reducing their ability to replicate. It has been shown in a large clinical study to shorten healing time by one to four days and to reduce discomfort. It should be applied as early as possible in the prodromal stage, and used five times a day for up to 10 days.

Lipactin contains heparin 17.8 units per gram and zinc sulfate 0.56 milligrams per gram as active ingredients that are also understood to reduce viral replication. It is recommended that the product be applied three to six times daily, beginning as soon as an outbreak is detected.

Natural alternatives
One alternative approach to preventing and treating cold sores takes into account the fact that the amino acid lysine inhibits the growth and spread of herpes simplex virus. Increasing consumption of lysine-rich foods (red meat, milk, eggs, cheese, wheat germ, brewer’s yeast, and fish) or taking supplements (e.g. 1000 mg three times daily) may help reduce the occurrence and shorten the duration of cold sores. The ratio of lysine to arginine is also important, as arginine inhibits absorption of lysine. Reducing consumption of foods rich in arginine, such as chocolate, peanuts and almonds, would increase the absorption of lysine. A pilot study conducted at the University of Southern California found that lysine ointment produced full resolution of cold sores in 40% of participants by the third day, and in 87% by the sixth day.

The herb, lemon balm (Melissa officinalis), has antiviral properties. In a study conducted in Germany, lemon balm cream promoted the healing of cold sore blisters in five days compared to 10 days in the control group. Used regularly on the affected area, it may reduce the frequency of recurrences.

Resveratrol, a compound found in red grapes, has also been shown to be active against the herpes simplex virus in laboratory studies. A study at Northeastern Ohio University found it to be as effective as 5% acyclovir ointment in suppressing cold sore development. It was also shown to be effective in animals with herpes simplex virus that was resistant to acyclovir. No side effects were reported.

Peppermint oil, also used in irritable bowel syndrome for its anti-spasmodic activity, also has been shown to penetrate the skin and have a direct virucidal effect against the herpes simplex virus. However, as the degree of absorption is not known it should not be given to patients with gastroesophageal reflux disease due to its ability to relax smooth muscle sphincters. It is also not recommended for patients taking calcium channel blockers as its relaxant action is believed to be similar in mechanism to this class of drug.

Immune stimulating herbs, such as Reishi (Ganoderma lucidum), astragalus and echinacea may be helpful in controlling cold sore outbreaks by strengthening the body defences that normally keep the virus in latent form. As a general caution, any patient with an autoimmune disorder, organ transplant, or liver disorder should consult their doctor before use. Keep in mind that Reishi reduces blood clotting and could affect anticoagulant therapy.

Erpace, marketed by Boiron, is designed to soothe pain and itching and promote healing of lesions. It contains essential oils of chamomile, oregano and marjoram, and lappa major mother tincture in a base of sweet almond oil. Oregano oil and marjoram oil are noted for their antiviral action while chamomile is an anti-inflammatory and an antiseptic. Lappa major (also known as burdock) is an antimicrobial that may also increase immunological activity.

For clients interested in homeopathic options, apis mellifica is recommended for use during the prodromal stage, rhus toxicodendron during the blister phase and mezerium would be suggested once the lesions have crusted over. Homeopathic medications are generally recommended up to 30CH dilution as OTCs (i.e. without the involvement of a qualified homeopath), and are dissolved under the tongue three to four times daily, or as often as every half hour in an acute situation. Homeopathic medication would be administered more frequently, rather than in larger quantities, to achieve a more intense and faster response.

There are many different approaches to treating and preventing cold sores, and they are not mutually exclusive. You may find, for example, that modifying the diet to increase absorption of lysine will complement a topical therapy. So, ask about additional treatment ideas the next time you seek help for a cold sore.

Originally published in Drugstore Canada

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Keeping Acne Under Control

Here’s a little “Acne 101” for the students in your life heading back to school, and for those like me who have acne-prone skin… what causes those blemishes and how to prevent and treat them!

Sebum (a waxy oily substance produced by glands in our skin), mixed with dead skin cells, blocks the openings to the pores, creating whiteheads or, if oxidized, blackheads. When oil and bacteria (specifically propionibacterium acnes [P. acnes]) become trapped in pores, the bacteria breaks the oil down into fatty acids that create irritation and inflammation along with the P.acnes infection. It is known that androgen (male hormone) stimulation causes changes in the pilosebaceous units (the oil-producing glands in hair follicles) that result in increased production of the problematic sebum.

The actual cause of acne is actually not well understood, but we do know that it is often associated with a hormone imbalance that involves increased androgen production, leading to excessive sebum production.

During adolescence, both males and females have increased levels of androgens and, in perimenopause and conditions such as polycystic ovarian syndrome, this type of hormone imbalance can occur also. Acne vulgaris, or common acne, affects areas that have the largest density of sebaceous follicles, and hence occurs most commonly on the face, upper chest and back.

Some sources have suggested that in certain skin types, the stratum corneum (the outside layer of skin), grows into the pore opening, creating a condition where pores are more easily blocked than in normal skin; other sources suggest that certain individuals may naturally produce a thicker sebum that blocks the pores more readily. Although these theories have not been well demonstrated, they could explain why some people have a greater tendency to develop acne than others.

Treatments are aimed at reducing oil, decreasing bacteria counts on the skin and keeping pores open. Many of our more effective acne treatments, such as correcting underlying hormonal imbalance, reducing sebum production with vitamin A derivatives, or reducing bacteria counts through antibiotic treatments, require prescription. However, there are many non-prescription options for mild to moderate acne problems. I am one of those unfortunates who have acne-prone skin so, although I generally try to base my articles on research-based information, forgive me if I take the liberty of adding a comment or two based on personal experience.

The 3-Step Approach
One trend we have seen in the acne marketplace is treatment “packages” that include a cleanser, toner and treatment cream or gel. A positive aspect of this idea is that it encourages acne sufferers to take a multiple strategy approach to treatment. Some of the more widely advertised products of this type (such as ProActiv and Acne Complex) are not available for sale in pharmacies and must be ordered by mail or Internet. However, it makes sense to simply select multiple products from the acne section with an understanding of the rationale for each, and create a customized “kit” for yourself.

Step 1: First, you want a mild cleanser, preferably soap-free, to remove excessive skin oils and some of the bacteria. The natural acidic nature of the skin is unfavourable to the growth of P. acnes and, as soaps are generally alkaline in nature, they can tend to reduce some of our natural resistance to these bacteria. Extra additives to the cleanser, such as keratolytics that mildly peel the skin, or benzoyl peroxide (discussed below), are thought to have little additional effect because of the short contact time with the skin.

While most sources recommend avoiding cleansers containing “scrubbing” particles that may increase inflammation, I have found personally that these can work well on non-inflamed acne-prone skin to prevent pores from becoming blocked by promoting exfoliation (or removal of the outer layer of dead keratin cells). Be aware, though, that many of these particles are made of plastics that can contaminate the environment – if you use one of these, choose one with natural, biodegradable particles.

Another option is to use an exfoliating sponge. Buff-Puff is one brand name, but they are available from many generic manufacturers. As exfoliation is also a common strategy for reducing the appearance of fine wrinkles, this may be an option that will interest older women with mild non-inflammatory acne. The use of an exfoliating sponge with a non-soap cleanser has been a personal favourite for 30 years; however, remember the caution against use in inflammatory acne.

Step 2: The second step, using a toner, often functions simply to remove more of the oil. Many toners have a high alcohol content, in the range of 30%, which may also kill some bacteria. Toners designed for use in acne often have 0.5 to 2% salicylic acid added, however, and this keratolytic agent, when left on the skin, can be useful to help keep pores open, preventing the trapping of oil and bacteria that is problematic in acne. Toners are designed to be applied using a cotton pad and are not rinsed from the skin afterward. Note that salicylic acid, an oil-soluble beta hydroxy acid, is often preferred in acne preparations for its ability to penetrate the oily sebum that is plugging the pores. It is sometimes referred to as a “comedolytic” action.

Some sources of information I have read in the past have suggested that alcohol alone may make an effective acne treatment, but many will complain that 70% alcohol causes burning and irritation while the lower content of alcohol in toners is generally tolerated quite easily. However, if you are a teen on a limited budget this might be a “step” to skip to reduce cost.

Conversely, an adult woman might appreciate this additional treatment from which she may benefit. As an example, one available multi-kit contains a toner with a low percentage of the alpha hydroxy acid (AHA) glycolic acid as an exfoliant to keep the pores open, while another has arnica added for its anti-inflammatory activity. A toner designed to reduce inflammation might be a welcome addition to the skincare regimen of a client with adult acne.

Step 3: The third step included in the multi-kits is a treatment gel or cream. There are numerous treatment products that we can recommend. My personal favourites, based both on theory and experience, are the benzoyl peroxide products. The maximum concentration that can be sold without prescription in Canada is 5% but in US the 10% is also out on the shelf. Most can easily tolerate 5%, but those with very sensitive skin may want to try a lower strength initially.

Be aware that benzoyl peroxide can increase sensitivity to the sun, so using it at bedtime and washing off in the morning makes sense, especially in the summer. As well, higher strengths, up to 10%, are available in Canada with a prescription. For me, a prescription for Panoxyl 10% alcohol gel was a turning point in acne control.

Benzoyl peroxide 10% would be a logical product to ask your pharmacists about, however, as they now have the ability to prescribe for acne in most jurisdictions. They would likely first ask questions about the severity of your problem, what you have already tried, and would verify that you had previously tolerated a 5% version of benzoyl peroxide.

As well as the tried and true OTC favourites, some alternative anti-acne ingredients have appeared in the literature and in various acne products. Here’s a little about how these ingredients are understood to work:

Arnica and calendula are herbal/homeopathic ingredients that have anti-inflammatory action. Calendula is also reported to have antibacterial activity.

Benzoyl peroxide is a favourite because of its dual action: it kills P. acnes bacteria plus has a keratolytic action. Don’t forget to ask about the 10% prescription if the 5% on the shelf doesn’t make a difference. Note: Be sure to use white towels and washcloths, as benzoyl peroxide will bleach coloured ones—I once ruined some of my Mom’s pretty green ones [sorry, Mom!].

Niacinamide (or nicotinamide) appears, when used as a 4 to 8% gel or cream, to have an anti-inflammatory effect and was shown to have comparable efficacy to topical clindamydin (a prescription antibiotic cream/lotion). It has also been credited with increasing synthesis of collagen and keratin, reducing skin hyperpigmentation (as can occur with acne scars), increasing skin moisture and reducing fine wrinkles. This is likely an ingredient that women with adult acne would be interested in. LaRoche-Posay’s Effaclar Duo Cream contains 8% niacinamide, or a pharmacist could compound this for you.

Resourcinol is included in acne products for its antiseptic action, presumably against P. acnes, and is often combined with the keratolytic, salicylic acid.

Sulfur, commonly found in acne products, is effective as a micro-exfoliant and a mild antiseptic and is probably the oldest known acne remedy, having been cited in ancient Greek, Roman and Chinese texts for this use. It is also helpful in promoting collagen synthesis, and is an active ingredient in lotions, creams, gels, washes and shampoos. It has also been used for seborrheic dermatitis, rosacea, eczema, psoriasis, and, in much higher concentrations, for scabies and lice.

Tea tree oil (5%) has been cited as being comparable in effect to benzoyl peroxide but without excessive drying, so might be a good option for adult acne. It kills P. acnes and has been shown to have anti-inflammatory action. It would also present a good option for those allergic or sensitive to benzoyl peroxide, or for those who are keen on a more natural option.

Zinc supplements, taken by mouth, have been shown to be helpful in inflammatory acne, although less so than oral tetracyclines (prescription antibiotic). Zinc tablets would also present an option for those who wish to avoid long-term antibiotics.

Camouflage techniques
Acne can be a distressing condition, particularly when it occurs at adolescence, a difficult time for many. It is natural for many teenagers, especially girls, to want to “cover up” their acne, and some advice from a pharmacist or trained cosmetician may help them to successfully do this without making their acne worse.

First, be sure to realize that bacteria, including the P. acnes that are involved in the acne process, can grow in your makeup products. Wash your hands before using, avoid dipping into the product with your fingers, and replace the products regularly. Use oil-free cosmetics to avoid adding additional oil to skin that is most likely already producing too much. Sheer or translucent makeup is recommended for commodonal acne, and fuller, opaque types for lesions or scars. You can also mix translucent powder with your makeup or dust it on afterward for better coverage. Multiple thin layers can be applied for additional coverage with drying time between.

Skin camouflage, such as Hyperflage, Dermablend, and CoverMark Face Magic, may be “just what the pharmacist ordered” for a teenager with acne heading to a special event. Proper application is important for best results and, generally, these products include instructions for use that should be read carefully to achieve a natural look. General recommendations are to cleanse the skin first, apply the camouflage makeup sparingly, blend the edges carefully, let dry, then apply foundation with a dry wedge sponge, if desired.

Previously published in Drugstore Canada

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Stress – The Elephant in the Room

Remember those predictions about working a four-day workweek in the new millenium? Well, it hasn’t worked out that way, has it! Computers and BlackBerrys, while making us more efficient, have also made us more accessible to work on evenings and weekends. Cutbacks often result in one person doing work that was previously assigned to several people. In my world, a lack of pharmacists often means long hours and less vacation time.

The result is increased stress—a contributing factor in many disease states that is rarely addressed in the course of a routine medical visit. Stress is listed as one of the modifiable causes of heart disease, and several of the effects of the stress hormone, cortisol, match up alarmingly with the symptoms of metabolic syndrome: increased blood pressure, weight gain around the waist, increased cholesterol and insulin resistance. Could it be that excess production of cortisol due to stress is that elusive cause of metabolic syndrome?

Researchers have observed that the appearance of cancer in many patients is preceded by a stressful event about two years earlier. Anyone who suffers from cold sores will tell you that they are most likely to show up when they are under stress. Emergency wards and student health centres note an increased demand for services during stressful times. Excessive production of cortisol is known to have a negative effect on the immune system, and the metabolic pathways by which this occurs have actually been identified. And stress hormones, being structurally similar to our reproductive hormones, can worsen the symptoms of menopause.

It’s enough to make you wonder why we don’t routinely test for and treat elevated cortisol blood levels…Perhaps it’s because physicians themselves have not been spared from the increased pace of life, and few are able to take time during an appointment to discuss the issues surrounding stress in a patient’s life.

Non-drug options for stress

Anti-depressants and tranquilizers are standard medications offered to highly stressed patients, but, as well as having high side effect profiles, they do not directly address the production of cortisol. However, in the herbal world, there are a number of medicines known as cortisol modifiers and adaptogens that lower cortisol production and lessen the impact of stress. As well, simple changes in lifestyle, attitudes and nutrition can result in a healthier response to the everyday stresses of life.

Those who really need help should be see a stress specialist. However, for those who are less severely stressed, I can pass along some self-help suggestions and recommend nonprescription supplements.

A good place to start is with a lifestyle assessment. Make a list of factors that are “good for me” versus “bad for me,” then devise a plan to relieve the worst factors, using a strategy to “change, adapt to, or leave” the most stressful situations. As stress hormones set up the body for “fight or flight,” exercise can be recommended to help reverse some of the effects of these hormones. Dietary recommendations to lower cortisol include eating balanced meals regularly throughout the day, ingesting a small amount of salt (sodium is required for adrenal function), avoiding simple sugars, increasing protein and essential fatty acids, and avoiding coffee, including decaffeinated (both contain theobromine, which tends to raise cortisol).

Substituting green tea for coffee, and vegetable juice for fruit juice is often advised. Vitamin C up to 3000 mg per day (either in divided doses or as a slow-release tablet) is recommended, as are B vitamins, particularly B5 or pantothenic acid, to support healthy adrenal function. Magnesium is a co-factor for many reactions that involve energy metabolism and nervous system function. Therefore the need for magnesium may be increased during periods of stress.

Magnesium is also necessary for muscle relaxation, and a deficiency increases the risk of muscle spasms that will often develop as a response to stress.

Herbal medications available for treating stress are divided into two major categories: the cortisol-modulating supplements (such as theanine, epimedium, and phytosterols) and the adaptogens or general anti-stress supplements (such as ginseng, schisandra, and astragalus). I will review some of the properties of some of these supplements to help distinguish which might be best for a particular client.

Cortisol modulating herbs

Theanine
Theanine is an amino acid. It acts as a non-sedating relaxant, helping to increase the brain’s production of alpha waves, one of the four basic brainwave patterns. Alpha wave production is associated with relaxed alertness, increased focus and concentration, promotion of creativity and improved overall mental performance. Theanine occurs naturally in tea leaves, and is converted by the plant gradually over time into catechins, the substance in tea known for its antioxidant benefits. Green tea, which is less aged than black tea, therefore contains more theanine than the other more aged varieties. As well, users should be aware that the decaffeination process removes theanine from tea along with the caffeine. Theanine has been shown in clinical studies to be effective in dosages from 50 to 200 mg per day. Three to four cups of green tea contain 100 to 200 mg of theanine. It is also available in supplement form.

Epimedium
Epimedium, also known as horny goat weed, has been shown to restore low levels of both testosterone and thyroid to normal levels, in addition to reducing cortisol levels when elevated. Hence, it has a reputation for improving libido in stressed individuals. Water-extracted epimedium, the traditional method of preparing this herb, is considered a safer form than the alcohol extract as rodent studies suggest that high doses of icariin, an alcohol-soluble constituent, may be associated with kidney and liver toxicity. A suggested dose for cortisol control is 250 to 1000 mg per day.

Phytosterols
Phytosterols include hundreds of plant-derived sterol compounds that are structurally similar to cholesterol but do not clog our arteries. By controlling production of inflammatory cytokines, phytosterols help modulate immune function, inflammation and pain levels. They have been shown to prevent immune system suppression and cortisol elevation usually seen in athletes after endurance events. Preliminary evidence from animal studies suggests that dietary phytosterols retard the growth and spread of breast cancer cells. Beta-sitosterol, one of the major phytosterols, has been shown in humans to normalize activity of T-helper lymphocytes and natural killer cells following stressful events that normally suppress immune system function. A typical dosage is 100 to 300 mg per day of mixed phytosterols, including 60 to 120 mg per day of beta-sitosterol. A handful of roasted peanuts or 2 tablespoons of peanut butter contain 10 to 30 mg of beta-sitosterol. Rice bran, corn, wheat germ and flaxseed are examples of rich food sources of phytosterols. See www.dietaryfiberfood.com for more information on the phytosterol content of foods.

Phosphatidylserine
Phosphatidylserine has been shown to modulate many aspects of cortisol overproduction, especially after intense exercise. There is scientific evidence that it can help improve mental function and depression, even in Alzheimer’s disease. Because cortisol causes catabolism of muscle tissue, athletes will frequently use this supplement to promote recovery from exercise and help slow muscle loss. Practitioners sometimes suggest phosphatidylserine supplements be taken late in the day to reduce nocturnal awakening due to surges in cortisol production during the night. Doses of 100 to 500 mg per day for one month are recommended for mental support, followed by a maintenance dose of 50 to 100 mg per day.

Tyrosine
Tyrosine is an amino acid that was studied by the U.S. military for its potential to help soldiers cope with the stress of battle. Their studies showed that 2000 mg of tyrosine helped memory and cognitive ability during stress. Studies, with volunteers exposed to stressful situations such as shift work, sleep deprivation and fatigue, found that 100 to 200 mg per day helped to prevent declines in mental performance and increased their ability to concentrate. Other amino acid groups, referred to as the branched chain amino acids (BCAAs) have been shown to counteract the rise in cortisol and drop in testosterone and immune function that is often seen in endurance athletes. Although tyrosine and BCAAs are available in supplement form, they can easily be obtained from protein foods. Hence, the recommendation above to increase protein content of the diet.

Adaptogenic herbs

Ginseng
Ginseng is the best known of the adaptogens. Many animal and human studies have shown that ginseng can increase energy and endurance, improve mental function and improve resistance to various stressors including infection, extreme exercise and sleep deprivation. Human studies have shown improved immune function and reduced incidence of colds and flu with Panax ginseng 100 mg per day. Siberian ginseng (Eleuthrococcus), while not a true ginseng, contains compounds that give similar effects. While generally considered safe, ginseng has been reported to increase blood pressure in some individuals, and caution should be used in those prone to hypoglycemia, due to its reported effect of reducing blood sugar levels.

Schisandra
Schisandra is a traditional Chinese medicine used to promote energy, protect the liver, alleviate exhaustion and correct immune system disturbances caused by stress. It is generally considered safe when used in recommended doses of 100-500 mg per day, although mild indigestion and skin rash has been reported. Because it may induce uterine muscle contractions, it should not be used by pregnant women.

Astragalus
Astragalus is an adaptogen herb commonly recommended for stimulation of the immune system and for energy-promoting properties. It has been used for centuries both in Traditional Chinese and Native American medicines, and animal experiments suggest that it enhances function of T-cells, lymphocytes and neutrophils. It is often combined with other adaptogenic herbs to keep the immune system functioning during periods of high stress. As a single ingredient it would be used in doses of 250 to 500 mg per day, or in combination as 100 to 200 mg per day.

Treating the cause

Many of these herbal medicines are available in combination “stress formula” products, and this is often the easiest way to supplement with them. People with high levels of stress on an ongoing basis would be well advised firstly to maintain a healthy diet and supplement with vitamin C, vitamin B complex and magnesium. If they are having difficulty coping with chronic stress or if stress is causing detrimental physical effects, they should next consider taking cortisol-modulating supplements as well. Adaptogenic herbs, available as combination products from several herbal manufacturers (for example: AdrenPlus from Enzymatic Therapy, Corti Lite from Vita Plus), would generally be used periodically during episodes of increased stress to counteract the detrimental effects of elevated cortisol.

Animal studies have shown that stress-induced rises in cortisol levels lead to increased visceral (in the abdominal cavity) fat deposits that are associated with disease states such as diabetes and heart disease. It would appear that we are focusing on treating all the diseases caused by excessive stress, while ignoring the “elephant” in the room. Perhaps the tools described above, along with improvements in diet and lifestyle, can help us to become healthier and improve our chances of avoiding chronic disease.

Originally published in Drugstore Canada